2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W708317
    (9Z,12Z)-15-Hydroxyoctadeca-9,12-dienoic acid 177931-23-6 98%
    (9Z,12Z)-15-Hydroxyoctadeca-9,12-dienoic acid (15(R)-Hydroxy-9(Z),12(Z)-octadecadienoic acid) is an ester product.
    (9Z,12Z)-15-Hydroxyoctadeca-9,12-dienoic acid
  • HY-W710380
    3-(Oleoyloxy)propane-1,2-diyl distearate 2190-29-6 99%
    1,2-Distearoyl-3-oleoyl-rac-glycerol is a triacylglycerol that contains stearic acid (HY-B2219) at the sn-1 and sn-2 positions and oleic acid (HY-N1446) at the sn-3 position. It has been found in cocoa butter and vegetable oils.
    3-(Oleoyloxy)propane-1,2-diyl distearate
  • HY-W710399
    2-Hydroxy-3-(palmitoyloxy)propyl stearate 17708-08-6 98%
    1-Palmitoyl-3-stearoyl-rac-glycerol is a diacylglycerol that contains palmitic acid (HY-N0830) at the sn-1 position and stearic acid (HY-B2219) at the sn-3 position. It has been found in palm-based diacylglycerols produced from palm stearin, palm mid fraction, palm oil, and palm olein, as well as in wheat bran and brewer’s spent grain extracts.
    2-Hydroxy-3-(palmitoyloxy)propyl stearate
  • HY-W710512
    Propane-1,2,3-triyl tritricosanoate-d5 98%
    Propane-1,2,3-triyl tritricosanoate-d5 (Glycerol Tritricosanoate-d5) is deuterium labeled Propane-1,2,3-triyl tritricosanoate. 1,2,3-Tritricosanoyl glycerol is a triacylglycerol that contains tricosanoic acid (HY-W009081) at the sn-1, sn-2, and sn-3 positions. It has been used as an internal standard for the quantification of fatty acids in the triglyceride component of human aortic endothelial cells (HAECs) grown in media supplemented with stearic and/or oleic acid.
    Propane-1,2,3-triyl tritricosanoate-d5
  • HY-W710954
    Pidobenzone 138506-45-3 98%
    Pidobenzone, an amino acid ester of hydroquinone, is a depigmenting agent. Pidobenzone can be used for the study of melisma.
    Pidobenzone
  • HY-W712534
    N-Acetyl lenalidomide 1421593-80-7
    N-Acetyl lenalidomide is a metabolite of Lenalidomide (HY-A0003), which is formed by hydrolysis of Lenalidomide in plasma and urine.
    N-Acetyl lenalidomide
  • HY-W713313
    3,5-DMA hydrochloride 24973-29-3 98%
    3,5-DMA (3,5-Dimethoxyamphetamine) hydrochloride is an alkylphenylamine compound primarily catalyzed by NAT2. The metabolic rate of 3,5-DMA hydrochloride is closely related to the NAT2 acetylator genotype variation. 3,5-DMA is useful for studying the role of NAT2 acetylator genotype variation in the metabolism of alkylphenylamine carcinogens.
    3,5-DMA hydrochloride
  • HY-W713414
    (Z)-Non-3-enal 31823-43-5 98%
    (Z)-Non-3-enal is an ester product.
    (Z)-Non-3-enal
  • HY-W713900
    MCPA-d3-1 2469242-78-0 98%
    MCPA-d3-1 is the deuterium labeled MCPA (HY-B0859). MCPA is an orally active phenoxyacetic acid herbicide. MCPA interferes with membrane integrity, energy metabolism (decreases ATP levels), and redox balance in plant cells. MCPA increases hepatic cytochrome P-450 levels and increases aniline hydroxylase and 7-ethoxycoumarin O-deethylase activities. MCPA can be used to control broadleaf weeds.
    MCPA-d3-1
  • HY-W713925
    Diheptanoyl Thio-PC 89019-63-6 98%
    Diheptanoyl Thio-PC is a substrate for all phospholipase A2s (PLA2s) with the exception of cPLA2 and PAF-acetyl hydrolase (PAF-AH).1 Interaction of this compound with a PLA2 results in cleavage of the sn-2 fatty acid generating a free thiol on the lysophospholipid. This free thiol can be detected using chromogenic substrates such as DTNB (Ellman’s reagent) and DTP.
    Diheptanoyl Thio-PC
  • HY-W714151
    Ganglioside ga1 71012-19-6 98%
    Ganglioside ga1 (Gg4cer; Asialoganglioside gm1; Asialo gm1, Gangliotetraosylceramide; Asialo ganglioside gm1a [...]; Ganglio-n-tetraosylceramide; Asialo gm1 ganglioside; Asialoganglioside gt1b) is an ester product.
    Ganglioside ga1
  • HY-W714541
    N-Acetyl-S-(2-cyanoethyl)-L-cysteine ammonium 168208-30-8 98%
    N-Acetyl-S-(2-cyanoethyl) -L-cysteine ammonium salt is the urinary metabolite of acrylamide in vivo.
    N-Acetyl-S-(2-cyanoethyl)-L-cysteine ammonium
  • HY-W715538
    Rhetsinine 526-43-2 98%
    Rhetsinine is an aldose reductase inhibitor isolated from Evodia rutaecarpa, exhibiting an IC50 value of 24.1 μM. At a concentration of 100 μM, rhetsinine significantly inhibits sorbitol accumulation by 79.3%. This compound shows potential for research in diabetic complications, including diabetic neuropathy and retinopathy.
    Rhetsinine
  • HY-W716865
    CBNQ 731773-46-9 98%
    CBNQ (Compound 22; Cannabinolquinone; HU-345) is an oxidative product of cannabinol.
    CBNQ
  • HY-W717125
    1-Palmitoyl-2-oleoyl-glycero-3-phosphoethanol sodium 322647-55-2 98%
    1-Palmitoyl-2-oleoyl-glycero-3-phosphoethanol (sodium) ((R)-Ethyl (2-(oleoyloxy)-3-(palmitoyloxy)propyl) phosphate (sodium)) is an ester product.
    1-Palmitoyl-2-oleoyl-glycero-3-phosphoethanol sodium
  • HY-W718023
    1,2-Dioctanoyl-3-chloropropanediol 95610-54-1 98%
    1,2-Dioctanoyl-3-chloropropanediol (3-Chloropropane-1,2-diyl dioctanoate) is an ester product.
    1,2-Dioctanoyl-3-chloropropanediol
  • HY-W718024
    3-Chloro-2-hydroxypropyl decanoate 3537-37-9 98%
    3-Chloro-2-hydroxypropyl decanoate is an ester product.
    3-Chloro-2-hydroxypropyl decanoate
  • HY-W718033
    1,2-Didecanoyl-3-chloropropanediol 2241680-20-4 98%
    1,2-Didecanoyl-3-chloropropanediol is an ester product.
    1,2-Didecanoyl-3-chloropropanediol
  • HY-W718034
    1,2-Didecanoyl-3-chloropropanediol-d5 2714473-28-4 98%
    1,2-Didecanoyl-3-chloropropanediol-d5 is deuterium labeled 1,2-Didecanoyl-3-chloropropanediol. 1,2-Didecanoyl-3-chloropropanediol is an ester product.
    1,2-Didecanoyl-3-chloropropanediol-d5
  • HY-W718035
    1-Chloro-3-(octanoyloxy)propan-2-yl decanoate 2468770-96-7 98%
    1-Chloro-3-(octanoyloxy)propan-2-yl decanoate is an ester product.
    1-Chloro-3-(octanoyloxy)propan-2-yl decanoate
Cat. No. Product Name / Synonyms Application Reactivity